Smoller Lab

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The Second Annual Conference on Precision Psychiatry: Innovation to Implementation

Presented by the MGH Center for Precision Psychiatry and PNGU

Save the date! The second annual Conference on Precision Psychiatry will be held on November 2nd and November 3rd, 2022 and will feature keynote speakers Kelsey Martin and Tom Insel. More details to come. 


Penetrance and Pleiotropy of Polygenic Risk Scores for Schizophrenia in 106,160 Patients Across Four Health Care Systems


Individuals at high risk for schizophrenia may benefit from early intervention, but few validated risk predictors are available. Genetic profiling is one approach to risk stratification that has been extensively validated in research cohorts.

Leaders of NIH’s All of Us Research Program recap progress and next steps


With information provided by volunteers across the United States, All of Us is developing a robust data platform to support a wide range of health studies. 

Exercise can reduce risk for depression study finds

CBS News

Researchers determined study participants who were genetically more likely to exercise may be less likely to develop depression.

Can't sleep? Could be down to genetics

Science Daily

Researchers have identified specific genes that may trigger the development of sleep problems, and have also demonstrated a genetic link between insomnia and psychiatric disorders such as depression, or physical conditions such as type 2 diabetes.

Why a Biobank May Soon Ask You For Your DNA and Medical Record


This summer, I got an email with the subject line, “Help researchers at Mass. General or the Brigham make discoveries.” Think the Boston hospitals — Massachusetts General Hospital and Brigham and Women's Hospital — were hitting me up for a check? Wrong.

Major mental illnesses unexpectedly share brain gene activity, raising hope for better diagnostics and therapies


Mental illness affects one in six U.S. adults, but scientists' sense of the underlying biology of most psychiatric disorders remains nebulous. That's frustrating for physicians treating the diseases, who must also make diagnoses based on symptoms that may only appear sporadically. No laboratory blood test or brain scan can yet distinguish whether someone has depression or bipolar disorder, for example.

Study: Depression, Autism And Schizophrenia Share Genetic Links


Attention deficit hyperactivity disorder, major depression, bipolar disorder and schizophrenia may be linked by common genetic risk factors, according to a new study published in The Lancet. Audie Cornish speaks with study author Jordan Smoller of Harvard Medical School.

Scientists link DNA variations to major depression for the first time

The Verge

For the first time, researchers have identified two genetic variants that predispose humans to major depressive disorder, according to a study published in Nature today. The finding is specific to Han Chinese women, so this isn't a universally relevant piece of information. Still, this discovery could help researchers get a handle on the biology of depression — in addition to enabling the identification of new drug targets.


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