Smoller Lab at PNGU

Our Team

Smoller Lab at PNGU

Our Team

Dr. Jordan Smoller

MD, SCD

Dr. Jordan Smoller is the MGH Trustees Endowed Chair in Psychiatric Neuroscience, Professor of Psychiatry at Harvard Medical School and Professor in the Department of Epidemiology at the Harvard School of Public Health in Boston. He is Associate Chief for Research in the Massachusetts General Hospital (MGH) Department of Psychiatry and Director of both the Psychiatric and Neurodevelopmental Genetics Unit and the Precision Medicine Research Unit in the MGH Center for Genomic Medicine. Dr. Smoller is a Tepper Family MGH Research Scholar and also serves as Director of the Omics Unit of the MGH Division of Clinical Research and co-Director of the Partners HealthCare Biobank at MGH. He is an Associate Member of the Broad Institute and a Senior Scientist at the Broad’s Stanley Center for Psychiatric Research. He is also Vice President of the International Society of Psychiatric Genetics.

The focus of Dr. Smoller’s research interests has been:

  • Understanding the genetic and environmental determinants of psychiatric disorders across the lifespan.
  • Integrating genomics and neuroscience to unravel how genes affect brain structure and function.
  • Using "big data", including electronic health records and genomics, to advance precision medicine.

He co-chairs the Cross-Disorder Workgroup of the international Psychiatric Genomics Consortium which has been examining how genetic influences transcend diagnostic boundaries. He is a PI in the Electronic Medical Records and Genomics (eMERGE) network and lead PI of the New England Precision Medicine Consortium as part of the NIH Precision Medicine Initiative’s All of Us Research Program. He is an author of more than 300 scientific publications and is also the author of The Other Side of Normal (HarperCollins/William Morrow, 2012).

Dr. Smoller's Team


Faculty

Kate Bentley

PHD

Kate Bentley, PhD is a clinical psychologist whose research focuses on the prediction and prevention of suicidal and nonsuicidal self-injurious thoughts and behaviors. Dr. Bentley received her doctorate in clinical psychology from Boston University and completed her clinical internship at MGH in the cognitive-behavioral therapy track. She is currently funded by a five-year NIMH career development award, mentored by Dr. Matthew Nock at Harvard University and Drs. Jordan Smoller and Maurizio Fava in the MGH Department of Psychiatry.

Tian Ge

PhD

Tian Ge, PhD is an applied mathematician and biostatistician who works at the intersection of neuroimaging science, genetics and statistics. His current research focuses on developing statistical and computational methods to integrate large-scale imaging, genomic, and biomedical data. Dr. Ge received his BS in Mathematics and PhD in Applied Mathematics from Fudan University, and a PhD in Computer Science from University of Warwick. He completed his postdoctoral training with Drs. Mert Sabuncu and Jordan Smoller at Massachusetts General Hospital and Harvard Medical School. He is currently an Instructor at Harvard Medical school, a junior faculty member in the Psychiatric & Neurodevelopmental Genetics Unit (PNGU), Center for Genomic Medicine, and is also affiliated with Athinoula A. Martinos Center for Biomedical Imaging at Massachusetts General Hospital. More information can be found on his personal webpage: https://scholar.harvard.edu/tge

Robbie Mealer

MD, PhD
Robbie Mealer, MD, PhD recently completed clinical residency in the MGH/McLean Adult Psychiatry Residency Program. He is currently an Instructor in Psychiatry at MGH and Harvard Medical School, Staff Psychiatrist at McLean Hospital, and the recipient of the Stanley Center Psychiatric Genetics and Neuroscience Fellowship and the MGH Translational Neuroscience Training for Clinicians Fellowship.  He received his undergraduate degree from Montana State University while performing basic neuroscience research with Thomas E. Hughes, PhD. He received his MD and PhD degrees from Johns Hopkins University School of Medicine, working in the lab of Solomon H. Snyder, MD. He is currently working with Dr. Jordan Smoller in the MGH PNGU on a project following up schizophrenia GWAS hits, looking for novel diagnostic and therapeutic biomarkers.

Randi Schuster

PhD
Randi Schuster, PhD is a neuropsychologist with specialized expertise in the cognitive ramifications of early drug exposure. She is currently funded by a five-year NIH NIDA career development award, mentored by Dr. Evins in the Center for Addiction Medicine and Dr. Smoller in the Psychiatric and Neurodevelopmental Genetics Unit.

Post-doctoral Fellows

Karmel Choi

PhD

Karmel Choi, PhD, is a postdoctoral fellow with Jordan Smoller, MD, ScD, and Karestan Koenen, PhD, through the T32 Training Fellowship in Psychiatric Genetics at the Harvard T.H. Chan School of Public Health. Her research focuses on the interplay of genetic and environmental factors that influence trauma and resilience across the life course. Her clinical work focuses on treatment of mood and anxiety disorders and stress-related health conditions, particularly in women. Karmel completed her PhD in Clinical Psychology at Duke University and her predoctoral clinical internship in Behavioral Medicine at MGH.

Anne Feng

PhD
Anne Feng, PhD works with Dr. Smoller at PNGU and Ben Neale, PhD, at ATGU. She graduated from Harvard T.H. Chan School of Public Health with a doctoral degree in genetic epidemiology. Her thesis focused on developing and applying statistical methods to a range of human -omics data, including GWAS, epigenomics, and metabolomics. She’s excited to explore the genetic underpinnings of and across neuropsychiatric traits, including projects to identify genetic variation affecting the risk of common epilepsies and to investigate cross-disorder relationships.

Heather Lee

PhD

Heather Lee, PhD, is a postdoctoral research fellow at PNGU, working with Dr. Jordan Smoller. She recently completed her PhD in psychiatric epidemiology from Brown University, focusing on prenatal immune activation as a potential predictor of offspring’s cognitive and psychiatric outcomes in the New England Family Study. During her postdoctoral training at PNGU, she’s excited to investigate the etiologic connections between immunological and psychiatric disorders using electronic health records and GWAS data.

Zhaowen Liu

PhD
Zhaowen Liu, PhD, is a postdoctoral fellow with Jordan Smoller, MD, ScD, and Tian Ge, PhD, at PNGU. She received her PhD in computer science from Xidian University with research topic on omics data analysis in cancers. In addition, she received her co-supervised PhD training at Fudan University worked on imaging genetics. Her research interests focus on developing and applying algorithms integrating omics data, EHRs and multimodal brain imaging data. Her focus at MGH will mainly on developing new data mining methods to explore the genetic and neural correlates of psychiatric disorders.

Yi-han Sheu

MD, SCD

Yi-han Sheu, MD, ScD, is a postdoctoral research fellow working with Dr. Smoller. He received his MD degree at National Taiwan University, MPH in Healthcare Management and Policy, and ScD in Epidemiology, both at Harvard University. His doctoral thesis involves using electronic health records data to improve treatment decision in psychiatric disorders by combining machine learning, artificial intelligence, and epidemiological methods. His current interest is in improving healthcare quality by further extending the application of the methodologies above, as well as making progress in more general aspects of artificial intelligence, such as improved transfer learning and multi-modal knowledge representations. 

Administrative Staff

Kristin Joyce

Kristin Joyce is the assistant to Dr. Jordan Smoller. Kristin has held this position for over five years and has become an integral part of the PNGU team.

Emily Madsen

BS

Emily Madsen graduated from SUNY Stony Brook University with a BS in biology specializing in developmental genetics. She previously worked closely with the clinical interpretation team of a clinical genetics laboratory focused on rare pediatric disorders. She is excited to learn more about complex trait genetics and psychiatric disorders.

Ashley Seiger-Jones

MSc
Ashley Seiger-Jones, MSc, is the Clinical Research and Administrative Program Manager for the Psychiatric and Neurodevelopmental Genetics Unit. Ashley has over a decade of clinical research experience and holds a Masters degree in Management, focused specifically on Research Administration. Ashley thrives on team inclusion and is passionate about streamlining processes to enhance study and team efficiencies across all phases of the research process.

Eugene Song

BA
Eugene is currently working in Jordan Smoller’s lab as a clinical research coordinator. Prior to joining the Smoller Lab, he graduated from Williams College with a BA in Chemistry and Chinese and worked as a counselor for adolescent psychiatric patients. He hopes to learn more about the widespread factors influencing psychiatric disorders and the innovative tools that can address them.

Smoller Lab Alumni


Visiting Investigators

Carolina Blaya
Soraya Seedat

Faculty

Avram Holms
John B. Levine
James Niels Rosenquist
Mert Sabuncu

Post-doctoral Fellows

Jennifer Barnett
Sarah Bergen
Shaunna Berkovitch
Stacy Drury
Laramie Duncan
Erin Dunn
Jinbo Fan
Chris Finn
Laura Germine
Stephen Gilman
Jie Huang
Phil Hyoun Lee
Jian Kong
John Levine
Lauren McGrath
Kate McLaughlin
Eric Morrow
Mireya Nadal-Vicens
Alisha Pollastri
Rachel Pollock
Joshua Roffman
Ben Schanker
Nadia Solovieff
Evelyn Stewart
Anna Wiste
Chia-Yen Chen

Resident Fellows

Christine Finn
Tamar Katz
Mireya Nadal-Vicens

Project Managers

Felicia Cerrato
Patience Gallagher
Stephen Haddad
Francine Molay
Priya Moorjani
Beth Rosen-Sheidley
Catherine Shain
Supriya Gupta
Heather Marino
Alison Hoffnagle

Office/Grants Managers

Erin Anderson
Talia Goldsmith
Jennifer Pinto
Samantha Schwartz
Katie Sklarsky
Jamie Weller

Administrative Staff

Lucille Lascuola-Chaput

Graduate Students

Jessica Agnew-Blais
Mei-hua Hall
Jian Kong
Yen-Feng Lin
Richie Siburian
Meg Wang
Vicki Wing
Qiu-Yue Zhong
Qunxi Zhu

Laboratory Managers

Jes Fagerness
Brian Galloway
Vered Levy

Laboratory Technicians

Sarah Andrus
Natalie Balkema
Aditi Basu
Jonathan Chaponis
Jaqueline Crane
Daisy Dai
Amanda Galenkamp
Allan Guiney
Boyd Gunnell
John Kennedy
Catherine Mayerfeld
Miles Nugent
Richie Siburian
Gerri Tangren
Lori Thomas
Jeff Toste
Jenna Tarasoff
Sarah Weatherall
Aaron Wolf
Lesley Yamaki

Research Coordinators

Sarah Andrus
Stefanie Block
Maria Bulzacchelli
Bridget Chak
Caitlin Clements
Yael Dai
Erica Gardner-Schuster
Connie Guille
Ruthann Hewett
Tamar Kaim
Stephanie Racette
Tiffany Stanton
Lisa Susswein
Lisa Watras
Sydney Weill
Candace White
Miriella Young

Student Interns

Noura Al-Juffali
Shannon Bean
Katherine Beattie
Jennifer Bourne
Breana Cazeau
Sofia Chua-Rubenfeld
Catherine Demers
Tomer Finkelberg
Jordan Hodges
John Hoffer
Rebecca Karlson
Dilsad Nur Kilicoglu
Wing Lam Kwan
Brendan Lang
Sam Levin
Lydia Lewis
Nicholas Merriam
Taylor Morson
Sony Mysore
Cameron Peebles
Sara Rubenstein
Liz Rubin
Malorie Snider
Jared Soundy
Zeke Vainer

LOCATION

Massachusetts General Hospital
Simches Research Building
185 Cambridge Street
Boston, MA 02114