Smoller Lab at PNGU

Our Team

Smoller Lab at PNGU

Our Team

Dr. Jordan Smoller

MD, SCD

Dr. Jordan Smoller is the MGH Trustees Endowed Chair in Psychiatric Neuroscience, Professor of Psychiatry at Harvard Medical School and Professor in the Department of Epidemiology at the Harvard School of Public Health in Boston. He is Associate Chief for Research in the Massachusetts General Hospital (MGH) Department of Psychiatry and Director of both the Psychiatric and Neurodevelopmental Genetics Unit and the Precision Medicine Research Unit in the MGH Center for Genomic Medicine. Dr. Smoller is a Tepper Family MGH Research Scholar and also serves as Director of the Omics Unit of the MGH Division of Clinical Research and co-Director of the Partners HealthCare Biobank at MGH. He is an Associate Member of the Broad Institute and a Senior Scientist at the Broad’s Stanley Center for Psychiatric Research. He is also Vice President of the International Society of Psychiatric Genetics.

The focus of Dr. Smoller’s research interests has been:

  • Understanding the genetic and environmental determinants of psychiatric disorders across the lifespan.
  • Integrating genomics and neuroscience to unravel how genes affect brain structure and function.
  • Using "big data", including electronic health records and genomics, to advance precision medicine.

He co-chairs the Cross-Disorder Workgroup of the international Psychiatric Genomics Consortium which has been examining how genetic influences transcend diagnostic boundaries. He is a PI in the Electronic Medical Records and Genomics (eMERGE) network and lead PI of the New England Precision Medicine Consortium as part of the NIH Precision Medicine Initiative’s All of Us Research Program. He is an author of more than 300 scientific publications and is also the author of The Other Side of Normal (HarperCollins/William Morrow, 2012).

Dr. Smoller's Team


Faculty

Kate Bentley

PHD

Kate Bentley, PhD is a clinical psychologist whose research focuses on the prediction and prevention of suicidal and nonsuicidal self-injurious thoughts and behaviors. Dr. Bentley received her doctorate in clinical psychology from Boston University and completed her clinical internship at MGH in the cognitive-behavioral therapy track. She is currently funded by a five-year NIMH career development award, mentored by Dr. Matthew Nock at Harvard University and Drs. Jordan Smoller and Maurizio Fava in the MGH Department of Psychiatry.

Karmel Choi

PHD

Karmel Choi, PhD, is a clinical psychologist and member of the faculty at Harvard Medical School. Her research uses methods from data science, epidemiology, and genetics to understand the etiology of stress-related conditions (e.g., depression, PTSD) and to identify actionable strategies for prevention and resilience promotion across the life course. Dr. Choi completed her PhD in Clinical Psychology at Duke University and her predoctoral clinical internship in Behavioral Medicine at Mass General. She also completed a postdoctoral T32 training fellowship in psychiatric genetics at the Harvard T.H. Chan School of Public Health. Dr. Choi’s clinical work focuses on the treatment of mood and anxiety disorders and stress-related health conditions.

Tian Ge

PhD

Tian Ge, PhD is an applied mathematician and biostatistician who works at the intersection of neuroimaging science, genetics and statistics. His current research focuses on developing statistical and computational methods to integrate large-scale imaging, genomic, and biomedical data. Dr. Ge received his BS in Mathematics and PhD in Applied Mathematics from Fudan University, and a PhD in Computer Science from University of Warwick. He completed his postdoctoral training with Drs. Mert Sabuncu and Jordan Smoller at Massachusetts General Hospital and Harvard Medical School. He is currently an Instructor at Harvard Medical school, a junior faculty member in the Psychiatric & Neurodevelopmental Genetics Unit (PNGU), Center for Genomic Medicine, and is also affiliated with Athinoula A. Martinos Center for Biomedical Imaging at Massachusetts General Hospital. More information can be found on his personal webpage and GitHub.

Robbie Mealer

MD, PhD
Robbie Mealer, MD, PhD recently completed clinical residency in the MGH/McLean Adult Psychiatry Residency Program. He is currently an Instructor in Psychiatry at MGH and Harvard Medical School, Staff Psychiatrist at McLean Hospital, and the recipient of the Stanley Center Psychiatric Genetics and Neuroscience Fellowship and the MGH Translational Neuroscience Training for Clinicians Fellowship.  He received his undergraduate degree from Montana State University while performing basic neuroscience research with Thomas E. Hughes, PhD. He received his MD and PhD degrees from Johns Hopkins University School of Medicine, working in the lab of Solomon H. Snyder, MD. He is currently working with Dr. Jordan Smoller in the MGH PNGU on a project following up schizophrenia GWAS hits, looking for novel diagnostic and therapeutic biomarkers.

Randi Schuster

PhD
Randi Schuster, PhD is a neuropsychologist with specialized expertise in the cognitive ramifications of early drug exposure. She is currently funded by a five-year NIH NIDA career development award, mentored by Dr. Evins in the Center for Addiction Medicine and Dr. Smoller in the Psychiatric and Neurodevelopmental Genetics Unit.

Christy Denckla

PhD

Dr. Christy A. Denckla is a clinical psychologist with joint appointments as a Research Associate in the Department of Epidemiology at the Harvard T.H. Chan School of Public Health, a Research Fellow at the Stanley Center for Psychiatric Research at the Broad Institute of MIT and Harvard, and an Instructor in Psychiatry at Massachusetts General Hospital. Her work aims to understand how adversity affects mental health and well-being across the lifespan, with a particular focus on bereavement. Dr. Denckla’s work is funded by an early career K23 award from NIMH, mentored by Drs. Karestan Koenen, Jordan Smoller, and Henning Tiemeier. She completed her postdoctoral fellowship in Psychiatric Epidemiology at the Harvard T.H. Chan School of Public Health, and her clinical internship at Massachusetts General Hospital, Harvard Medical School. Her doctoral research was completed at Adelphi University in New York.

Fellows

Heather Lee

PhD

Heather Lee, PhD, is a postdoctoral research fellow at PNGU, working with Dr. Jordan Smoller. She recently completed her PhD in psychiatric epidemiology from Brown University, focusing on prenatal immune activation as a potential predictor of offspring’s cognitive and psychiatric outcomes in the New England Family Study. During her postdoctoral training at PNGU, she’s excited to investigate the etiologic connections between immunological and psychiatric disorders using electronic health records and GWAS data.

Zhaowen Liu

PhD
Zhaowen Liu, PhD, is a postdoctoral fellow with Jordan Smoller, MD, ScD, and Tian Ge, PhD, at PNGU. She received her PhD in computer science from Xidian University with research topic on omics data analysis in cancers. In addition, she received her co-supervised PhD training at Fudan University worked on imaging genetics. Her research interests focus on developing and applying algorithms integrating omics data, EHRs and multimodal brain imaging data. Her focus at MGH will mainly on developing new data mining methods to explore the genetic and neural correlates of psychiatric disorders.

Yi-han Sheu

MD, MPH, SCD
Yi-han Sheu, MD, MPH, ScD, is a postdoctoral research fellow working with Dr. Smoller. He received his MD degree at National Taiwan University, and completed residency and fellowship training in psychiatry at National Taiwan University Hospital. He then went on to complete degrees of MPH in Healthcare Management and Policy, and ScD in Epidemiology, both at Harvard University. His doctoral thesis involves using electronic health records data to improve treatment decision in psychiatric disorders by combining machine learning, artificial intelligence, and epidemiological approaches. He is currently interested in increasing medical care precision by further extending the application of the methodologies above, and to achieve so, improving its prerequisites in general artificial intelligence, such as model interpretation and robustness, incorporation of causal inferential methods, effective transfer learning, and building multi-modal knowledge representations.

Bo Wang

PHD
Bo Wang, PhD, is a postdoctoral research fellow at PNGU, working with Dr. Jordan Smoller. He received his PhD in natural language processing from University of Warwick, followed by postdoctoral training at Department of Psychiatry, University of Oxford and the Alan Turing Institute. He is interested in learning patient representation and modelling patient health trajectory from multi-modal data including clinical notes from EHRs. His current research focuses on suicide risk prediction and developing methods to improve the selection of treatments for depression.

Travis Mallard

PhD

Travis Mallard, PhD is a clinical psychologist whose research is focused on understanding the etiology of psychiatric disorders, with a particular interest in forms of psychopathology that are characterized by disinhibition and/or psychosis. He is currently a postdoctoral research fellow at the Psychiatric & Neurodevelopmental Genetics Unit and the Center for Genomic Medicine, where he is working with Dr. Jordan Smoller to advance understanding of comorbidity and bridge levels of analysis in psychiatric genetics. Travis completed his doctoral training in clinical psychology at the University of Texas at Austin, and he received additional training in statistical genetics and imaging genetics at the Vrije Universiteit Amsterdam and the National Institute of Mental Health, respectively.

Residents

Eric Ross

MD

Eric Ross, MD is a resident psychiatrist at MGH and McLean Hospital. He graduated from Dartmouth College with a neuroscience/chemistry degree in 2011 and from the University of Michigan Medical School in 2018. His research focuses on the use of population-level mathematical modeling to address issues in public health, health economics, and clinical decision-making. At MGH, he's working on projects evaluating the health-economic effects of suicide risk prediction, the cost-effectiveness of novel treatments for depression, and the approach to testing for medical causes of first-episode psychosis.

Data Analysts

Hyunjoon Lee

MS

Hyunjoon Lee is a Senior Data Analyst in Jordan Smoller’s lab at the PNGU. At Smoller Lab, Hyunjoon focuses on analyzing and modeling using electronic health records data. Prior to joining the Smoller Lab, he was a data scientist for a tech start-up. He holds a BS in Computer Science and MS in Data Science from Brown University. He is especially interested in suicide prediction and interventions and hopes to earn his PhD in psychiatric epidemiology in the future.

Administrative Staff

Kristin Joyce

Kristin Joyce is the assistant to Dr. Jordan Smoller. Kristin has held this position for over five years and has become an integral part of the PNGU team.

Rebecca Luh

BA

Rebecca Luh earned her BA in biology from Carleton College where she worked in a behavioral neuroscience lab investigating interactions between hormones and the brain that occur during puberty. This research led her to PNGU where she is excited to learn more about genetic determinants of brain function and structure as well as predictive modeling of psychiatric disorders.

Emily Madsen

BS

Emily Madsen graduated from SUNY Stony Brook University with a BS in biology specializing in developmental genetics. She previously worked closely with the clinical interpretation team of a clinical genetics laboratory focused on rare pediatric disorders. She is excited to learn more about complex trait genetics and psychiatric disorders.

Ashley Seiger-Jones

MSc
Ashley Seiger-Jones, MSc, is the Clinical Research and Administrative Program Manager for the Psychiatric and Neurodevelopmental Genetics Unit. Ashley has over a decade of clinical research experience and holds a Masters degree in Management, focused specifically on Research Administration. Ashley thrives on team inclusion and is passionate about streamlining processes to enhance study and team efficiencies across all phases of the research process.

Eugene Song

BA
Eugene is currently working in Jordan Smoller’s lab as a clinical research coordinator. Prior to joining the Smoller Lab, he graduated from Williams College with a BA in Chemistry and Chinese and worked as a counselor for adolescent psychiatric patients. He hopes to learn more about the widespread factors influencing psychiatric disorders and the innovative tools that can address them.

Marina Wilson

BS

Marina Wilson is a Clinical Research Coordinator in the Smoller Lab. She has earned her BS in Psychology from Northeastern University. She has previously worked in an outpatient clinic for youth and adolescent supporting different programs and research projects. She is excited to learn more about the innovative tools used to examine various psychiatric disorders. 

Interns

Anushka Kumar

Anushka Kumar is a student intern at Dr. Smoller’s lab from Scarsdale High School. She is most interested in preventing mood and anxiety disorders by mitigating the impact of genetic risk through environmental modifications as well as integrating mental health support into primary care. She is extremely excited to experience the process of research and learn from experts in the field. 

Smoller Lab Alumni


Visiting Investigators

Carolina Blaya
Soraya Seedat

Faculty

Avram Holms
John B. Levine
James Niels Rosenquist
Mert Sabuncu

Post-doctoral Fellows

Jennifer Barnett
Sarah Bergen
Shaunna Berkovitch
Stacy Drury
Laramie Duncan
Erin Dunn
Jinbo Fan
Chris Finn
Laura Germine
Stephen Gilman
Jie Huang
Phil Hyoun Lee
Jian Kong
John Levine
Lauren McGrath
Kate McLaughlin
Eric Morrow
Mireya Nadal-Vicens
Alisha Pollastri
Rachel Pollock
Joshua Roffman
Ben Schanker
Nadia Solovieff
Evelyn Stewart
Anna Wiste
Chia-Yen Chen
Amanda Zheutlin
Anne Feng
Karmel Choi
Whitney McFadden
Andrew Grotzinger

Resident Fellows

Christine Finn
Tamar Katz
Mireya Nadal-Vicens

Project Managers

Felicia Cerrato
Patience Gallagher
Stephen Haddad
Francine Molay
Priya Moorjani
Beth Rosen-Sheidley
Catherine Shain
Supriya Gupta
Heather Marino
Alison Hoffnagle

Office/Grants Managers

Erin Anderson
Talia Goldsmith
Jennifer Pinto
Samantha Schwartz
Katie Sklarsky
Jamie Weller

Administrative Staff

Lucille Lascuola-Chaput

Graduate Students

Jessica Agnew-Blais
Mei-hua Hall
Jian Kong
Yen-Feng Lin
Richie Siburian
Meg Wang
Vicki Wing
Qiu-Yue Zhong
Qunxi Zhu

Laboratory Managers

Jes Fagerness
Brian Galloway
Vered Levy

Laboratory Technicians

Sarah Andrus
Natalie Balkema
Aditi Basu
Jonathan Chaponis
Jaqueline Crane
Daisy Dai
Amanda Galenkamp
Allan Guiney
Boyd Gunnell
John Kennedy
Catherine Mayerfeld
Miles Nugent
Richie Siburian
Gerri Tangren
Lori Thomas
Jeff Toste
Jenna Tarasoff
Sarah Weatherall
Aaron Wolf
Lesley Yamaki

Research Coordinators

Sarah Andrus
Stefanie Block
Maria Bulzacchelli
Bridget Chak
Caitlin Clements
Yael Dai
Erica Gardner-Schuster
Connie Guille
Ruthann Hewett
Tamar Kaim
Stephanie Racette
Tiffany Stanton
Lisa Susswein
Lisa Watras
Sydney Weill
Candace White
Miriella Young

Student Interns

Noura Al-Juffali
Shannon Bean
Katherine Beattie
Jennifer Bourne
Breana Cazeau
Sofia Chua-Rubenfeld
Catherine Demers
Tomer Finkelberg
Jordan Hodges
John Hoffer
Rebecca Karlson
Dilsad Nur Kilicoglu
Wing Lam Kwan
Brendan Lang
Sam Levin
Lydia Lewis
Nicholas Merriam
Taylor Morson
Sony Mysore
Cameron Peebles
Sara Rubenstein
Liz Rubin
Malorie Snider
Jared Soundy
Zeke Vainer

LOCATION

Massachusetts General Hospital
Simches Research Building
185 Cambridge Street
Boston, MA 02114